πŸ– Table 1 Phase II and phase III trials of levosimendan in patients hospitalized for HF

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Results of CASINO trial | Find, read and cite all the research you need on failure: New confirmation of benefits of levosimendan and dangers of dobutamine​.


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CASINO trial, , , Dobutamine, placebo, Assigned to treatment at 48 h into hospitalization, IV, NA, 6 months, All-cause mortality, % (levosimendan) vs.


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In the Levosimendan Infusion versus Dobutamine (LIDO) trial, patients with low Sensitizer or Inotrope or None in Low-Output Heart Failure (CASINO) trial,​.


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study (CASINO) recently suggested mortality benefits with levosimendan over placebo and dobutamine. Currently, two large prospective trials (SURVIVE and.


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Dobutamine (LIDO) trial, which enrolled patients, and the Calcium Sensitizer or Inotrope or None in Low Output Heart Failure (CASINO).


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with slide / Results of the CASINO study suggest that the new calcium They also suggest that dobutamine is detrimental in this condition. failure, the LIDO trial, showed that the new drug was superior to dobutamine in.


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The LIDO trial examined patients similar to the present case (low output heart of |xg/kg per minute) or dobutamine (5β€”10 jJLg/kg per minute) each for 24 hours. The CASINO study was designed to enroll patients with acute​.


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Levosimendan infusion duration was 23 hours and dobutamine infusion was 39 In a meta-analysis of the LIDO, CASINO and SURVIVE trials.


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Methods: Clinical trials were searched in PubMed, EMBASE, and the Cochrane Conclusions: In contrast with dobutamine, levosimendan is associated with a With the inclusion of the CASINO study, the result of analysis in.


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with slide / Results of the CASINO study suggest that the new calcium They also suggest that dobutamine is detrimental in this condition. failure, the LIDO trial, showed that the new drug was superior to dobutamine in.


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Br J Pharmacol , β€” J Cardiovasc Pharmacol , 29 β€” Circulation , β€” This study demonstrates that the hemodynamic effects of levosimendan are sustained after stopping a hour infusion because of the presence of long-acting metabolites. Levosimendan has been extensively studied in various animal models of heart failure, in which the drug has increased contractility without adverse effects on diastolic function. Its mechanism of action includes calcium sensitization of contractile proteins and the opening of adenosine triphosphate-dependent K channels. Clin Pharmacol Ther , 68 β€” This study demonstrates the hemodynamic efficacy of levosimendan in patients with advanced heart failure. The combination of positive inotropy with antiischemic effects of K-channel opening offers potential benefits in comparison with currently available intravenous inotropes, which are contraindicated in patients with ongoing myocardial ischemia. Circulation , 98 β€” Cardiovasc Res , 34 β€” Anesthesiology , 81 β€” Udvary E, Papp JG, Vegh A: Cardiovascular effects of the calcium sensitizer, levosimendan, in heart failure induced by rapid pacing in the presence of aortic constriction. J Cardiovasc Pharmacol , 31 β€” J Pharmacol Exp Ther , β€” J Mol Cell Cardiol , 30 β€” Circ Res , 77 β€” This article demonstrates the calcium-sensitizing effect of levosimendan and evaluates the relative contribution of cAMP-dependent and cAMP-independent actions of the drug. Cardiovasc Drug Rev , 14 β€” J Biol Chem , β€” This study describes the interaction of levosimendan with troponin C. Taxes to be calculated in checkout. Am J Cardiol , 83 Suppl 12B β€” New Orleans, LA; March 7β€”10, Abstract presented at the ESC Congress Vienna, Austria; August 30 to September 3, Int J Clin Pharmacol Ther , 41 β€” Am J Cardiol , 83 Suppl 12B :4β€”8.

Levosimendan is a new inodilator. Abstract Levosimendan is a new inodilator. These trials will conclusively prove whether levosimendan should be added to the standard treatment in patients who are hospitalized because of cardiac decompensation. J Casino trial dobutamine Pharmacol42 β€” Eur J Pharm Sci9 β€” J Am Coll Cardiol36 β€” This article describes in detail the casino trial dobutamine hemodynamic effects of levosimendan.

Anesth Analg85 β€” Eur Heart J19 β€” J Cardiovasc Pharmacol34 β€” Sonntag S, Sundberg S, Lehtonen L, Kleber F: The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia.

Hosenpud JD, the Oral Levosimendan Casino trial dobutamine Group: Levosimendan, a novel myofilament calcium sensitizer, allows weaning of parenteral inotropic therapy in patients with severe congestive heart failure.

J Am Coll Cardiol22 β€” Ver Donck L: Calcium-sensitizing drugs: positive inotropy by enhanced sensitivity just click for source the contractile apparatus to calcium.

References and Recommended Reading 1. Issue Date : September Search SpringerLink Search. Reprints and Permissions. Lehtonen, L. It shows that levosimendan is superior in reducing PCWP of patients with decompensated heart failure and is better tolerated than dobutamine.

These results have been repeated in patients with heart failure, in whom levosimendan dosedependently increases cardiac output and reduces pulmonary capillary wedge pressure.

Lancetβ€” This double-blind study compares levosimendan and dobutamine. J Am Coll Cardiol43 β€” Eur Heart J18 β€” This is the first controlled study with any intravenous drug for heart casino trial dobutamine in patients with acute myocardial infarct.

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Prog Cardiovasc Dis41 β€” Clin Pharmacokinet43 β€” Feldman AM: Classification of positive inotropic agent. N Engl J Medβ€” Vesnarinone Trial Investigators. Rent this article via DeepDyve. Casino trial dobutamine J Cardiol83 Suppl 12B :9β€” Drugs63 β€” J Cardiovasc Pharmacol35 β€” Google Scholar.

About this article Cite this article Lehtonen, L.

Levosimendan: A calcium-sensitizing agent for the treatment of patients with decompensated heart failure. J Mol Cell Cardiol , 27 β€” J Cardiovasc Pharmacol , 25 β€” J Mol Cell Cardiol , 35 β€” Eur J Pharmacol , β€” Pharmacol Toxicol , 74 β€” Anesth Analg , 90 :5β€” This study shows that the anti-ischemic actions of levosimendan are based on its effect on ATP-dependent K channels. Rights and permissions Reprints and Permissions. The active metabolite of levosimendan OR significantly prolongs the duration of the hemodynamic effects of the therapeutic hour levosimendan infusion. Curr Heart Fail Rep 1, β€” Download citation. It shows that levosimendan in low and medium doses is well-tolerated in these patients and suggests that the drug improves their survival. This is a preview of subscription content, log in to check access.